Catabolism steps of branched chain amino acids

Truck hit the Ox to Death”:

  • Transamination
  • Oxidative decarboxylation
  • Dehydrogenation


Essential amino acids


  • Phe
  • Val
  • Thr
  • Trp
  • Ile
  • Met
  • His
  • Arg
  • Leu
  • Lys

Pvt. is short for Private in the military.

Arg and His are considered semiessential.

Alternatively: “MATT VIL PHLy”.


Essential amino acids

PVT. TIM HALL always argues, never tires”:

  • Phe
  • Val
  • Thr
  • Trp
  • Ile
  • Met
  • His
  • Arg
  • Lue
  • Lys

Always argues: the A is for Arg, not Asp.

‘Never tires’: T is not Tyr, but is both Thr and Trp.


Fasting state: branched-chain amino acids used by skeletal muscles

“Muscles LIVe fast”:

  • Leucine
  • Isoleucine
  • Valine

 AcetylCoA and acetacetylCoA: amino acids forming them

A Lighter Lease” (A LyTr LeIs):

  • A=AcetylCoA or Acetoacetyl CoA
  • Ly=Lysine
  • Tr=Tryptophan
  • Le=Leucine
  • Is=Isoleucine

BUN:creatinine elevation: causes


  • Azotremia (pre-renal)
  • Bleeding (GI)
  • Catabolic status
  • Diet (high protein parenteral nutrition)

Creatine phosphate: amino acid precursors

“Nice GAMs!”:

  • Glycine
  • Arginine
  • Methionine

Gam is slang for a person’s leg, especiallay an attractive female’s leg: “Nice gams = nice legs!”

Creatine phosphate is a muscle energy store, and spontaneously converts to creatinine which is excreted in the urine in direct proportion to muscle mass: clinically useful, such as in MS Dx.


Nitric oxide: amino acid precursor

When the dentist works on your teeth, you say, “AAArg! (Arginine)” before he administersNitric Oxide (NO) to take the pain away.

Other players necessary for NO synthesis: NO synthase, Ca++, NADPH.

Urea Cycle
Ordinarily, Careless Crappers, Are Also Frivolous About Urination.

  • Ornithine
  • Carbamoyl
  • Citrulline
  • Arginosuccinate
  • Aspartate
  • Fumarate
  • Arginine
  • Urea

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