G protein type for respective receptors
“KISS and KICK till you’re SICK of SEX” (QISS and QIQ till you’re SIQ of SQS):
This gives the G-protein type (Gq, Gi, or Gs) for all the receptors. Receptors are in alphabetical order:
Golgi complex: functions
“Golgi Distributes A SPAM“:
- Distributes proteins and lipids from ER
- Add mannose onto specific lysosome proteins
- Sulfation of sugars and slected tyrosine
- Proteoglycan assembly
- Add O-oligosugars to serine and threnonine
- Modify N-ologosugars on asparagine
Metabolic acidosis (normal anion-gap): causes
With hyperkalemia: RAISE K+:
- RTA type 4
- Aldosterone or mineralocorticord deficiency
- Iatrogenic: NH4Cl, HCl
- “Stenosis”: obstructive uropathy
- Early uremia
With hypokalemia: ReDUCE K+:
- Renal TA type 1 and 2
- Urine diversion into gut
- Carbonate anhydrase inhibitor
“Use both arms to HUG“:
- Heme synthesis
- Urea cycle
These reactions occur in both cytoplasm and mitochondria.
Na/K pump action
(Sing loudly to the chorus of “Kiss Him Goodbye”): “Na, Na, Na — out! Na, Na, Na — out! K, Kgoes…inside!”
Action of pump is 3 Na out and 2 K in
Na/K pump: concentrations of Na vs. K on inside/outside of cell, pump action, number of molecules moved
There is a HIgh K concentration INside the cell.
From this can deduce that the Na/K pump pumps K into cell and Na out of cell.
Alternatively: When I was learning this pump (circa 1992), a band that was “in” was Kris Kross, and a band that was “out” was “Sha Na Na Na“:
So pump moves K K (2 K) in and Na Na Na (3 Na) out.
Sadly, as infectious as their debut album was, Kris Kross can really no longer be classed as “in”.
Na+/K+ pump: movement of ions and quantity
K+ and in each consist of 2 characters, so so 2 K+ are pumped in.
Na+ and out each consist of 3 characters, so 3 Na+ are pumped out.
Tangier’s disease: hallmark
Hallmark is large orange tonsils.
Important clinical note: there is no increased risk of atherosclerosis, just like eating tangerenes.
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