Van den Bergh reaction (Jaundice test)
“Indirect reacting bilirubin = Unconjugated bilirubin”:
Both start with vowels, so they go together: Indirect & Unconjugated.
Heme synthesis: amino acid precursors to basic unit of porphyrins, heme (pyrrole ring)
“Dracula wants to Suck a Co-ed’s blood [think heme] with his Glystening teeth!”:
Succinyl CoA and Glycine are precursor amino acids to pyrrole rings, which is the basic unit of porphyrins and heme.
Hemoglobin binding curve: causes of shift to right
“CADET, face right!”:
- 2,3-DPG (aka 2,3 BPG)
Porphyrias: acute intermittent porphyria symptoms
- Pain in abdomen
- Psychologial abnormalities
- Pink urine
- Precipitated by drugs (eg barbiturates, oral contraceptives, sulpha drugs)
Sickle cell anemia: mutation
“HbS isn’t Very Good”:
At Sixth position of HB beta chain, Valine is present instead of Glutamic acid.
Sickle cell disease pathophysiology
SICKle cell disease is due to a Substitution of the SICKsth amino acid of the B chain.
Vitamin K dependent cofactors
“Several Tend To Nicely Stop Clots”:
Factor Seven, Ten, Two, Nine.
Protein S, Protein C.
Coagulation common pathway: factors in order
10 + 5 – 2 = 13
Coagulation common pathway:
Factor X to Factor V to Factor II to Factor XIII