Practice Paper 3

  1. Serum lipoprotein with highest cholesterol content is
    1. Prealbumin
    2. Chylomicrons
    3. Alpha lipoprotein
    4. Beta lipoprotein
  2. Endogenous triglycerides in plasma is maximally bound to
    1. Chylomicorns
    2. LDL
    3. VLDL
    4. HDL
  3. The apoprotein in LDL is
    1. B-48
    2. A-1
    3. C
    4. B-100
  4. Phenylalanine is the precursor of all the following except
    1. Tyrosine
    2. Epinephrine
    3. Thyroxine
    4. Melatonin
  5. Sources of the nitrogen in urea cycle are
    1. Aspartate and ammonia
    2. Glutamate and ammonia
    3. Arginine and ammonia
    4. Uric acid
  6. Chaperone proteins are
    1. Needed for initiating protein synthesis
    2. Required for post translational covalent alteration of proteins
    3. Required for proper folding of proteins
    4. Essential for quaternary structure of proteins
  7. Xanthurenic acid is formed in the metabolism of
    1. Tryptophan
    2. Tyrosine
    3. Histidine
    4. Alanine
  8. All of the following are essential amino acids except
    1. Tyrosine
    2. Lysine
    3. Methionine
    4. Threonine
  9. Musty odour is seen in
    1. Alkatonuria
    2. Phenylketonuria
    3. Oxalosis
    4. Cystinuria
  10. Hydroxy proline is present in
    1. Keratin
    2. Elastin
    3. Collagen
    4. Laminin
  11. In pyrimidine sythesis required is:
    1. Carbamoy P I
    2. Carbamoyl P II
    3. Both
    4. None of the above
  12. Purines metabolise to form:
    1. Urea
    2. Uric acid
    3. Bence Jones proteins
    4. All of the above
  13. The first nucteolide made by de novo purine nucleotide biosynthesis is
    1. AMP
    2. GMP
    3. IMP
    4. DUMP
  14. Lesch nyhan syndrome is due to deficiency of
    1. Hypoxanthine phosphoribosyl transferase
    2. Xanthine oxidase
    3. Purine phoshorylase
    4. Adenosine deaminase
  15. Selenium is essential for the
    1. Glutathione peroxidase
    2. Glutathione reductase
    3. Glutathione synthetase
    4. Glutathione hydroxylase
  16. Cobalt is necessary for
    1. Pyridoxine
    2. Folic acid
    3. Vitamin B12
    4. Thiamine
  17. Ferritin, is stored in
    1. Gut
    2. Spleen
    3. Liver
    4. All of the above
  18. Copper binds with
    1. Transferrin
    2. Ceruloplasmin
    3. Beta globulin
    4. Hemoglobin
  19. Which of the following RNA has abnormal purine bases
    1. T RNA
    2. M RNA
    3. R RNA
    4. 16SRNA
  20. Translation occurs in
    1. Ribosomes
    2. Mitochondria
    3. Nucleus
    4. Cytoplasm
  21. Okazakisegments are required for
    1. DNA synthesis
    2. RNA synthesis
    3. Protein synthesis
    4. None of  the above
  22. Which of the following enzyme is called ‘reverse transcriptase’
    1. DNA dependent DNA polymerase
    2. DNA dependent RNA polymerase
    3. RNA dependent RNA polymerase
    4. RNA dependent DNA polymerase
  23. Histamine is produced by
    1. Oxidation
    2. Reduction
    3. Carboxylation
    4. Decarboxylation
  24. Enzymes mediating transfer of one molecule to another are
    1. Transferees
    2. Oxidases
    3. Lysases
    4. Peptidases
  25. Best enzyme marker for chronic alcoholism is
    1. Gamma glutamyl –transferase
    2. SGOT
    3. SGPT
    4. Aldolase
  26. KM of an enzyme is always
    1. One half of the VMAX
    2. Dissociation constant
    3. Normal substrate concenteration
    4. Substrate Con. that gives half maximal velocity
  27. Abzyme is
    1. Abnorma enzyme
    2. Synthetic antibody catalytic properties
    3. Antibodies to enzyme
    4. Isozyme
  28. In ‘competitive inhibition’ of enzyme reaction
    1. Km remains unchanged
    2. V max is decreased
    3. Efficiency deft-eases
    4. V max remains same and KM is increased
  29. Antioxidant vitamins are all except
    1. Vitamin C
    2. Vitamin E
    3. Vitamin D
    4. b-carotine
  30. Post translational defect in scurvy is non hydroxylation of
    1. Proline
    2. Glycine
    3. Isoleucine
    4. Leucine
  31. Pyridoxal phosphate is coenzyme in
    1. Deamination
    2. Decarboxylation
    3. Transamination
    4. All of the above
  32. FIGLU excretion is diagnostic for
    1. Leucine
    2. Lysine
    3. Tyrosine
    4. Histidine
  33. Co factor for decarboxylation is
    1. B1
    2. B6
    3. B2
    4. Biotin
  34. Methylmalonic aciduria is due to deficiency of
    1. Vit B1
    2. Vit B2
    3. Vit B6
    4. Vit B12
  35. Which respond to B6 therapy
    1. Down’s
    2. Phenylketonuria
    3. Homocystinuria
    4. Lactose intolerance
  36. Substrate level phosphorylation is seen in the conversion of
    1. Acetoacetate to a –keto glutarate
    2. Succinyl coA to succinate
    3. Fumarate to malate
    4. Succinate to fumarate
  37. NADPH is required for
    1. Gluconeogenesis
    2. Glycolysis
    3. Fatty acids synthesis
    4. Glycogenolysis
  38. Heriditary fructose intolerance is a conduction caused by deficiency of
    1. Phosphatnectokinase
    2. Fructokinase
    3. Phosphofructoaldolase
    4. Fructose –6 phosphate
  39. In galactosemia , there is deficiency of
    1. Galactosidase
    2. Galactose 1-phosphate uridyl transferase
    3. Aldolase reductase
    4. UDP-Hexose 4 epimerase
  40. Hexokinase is a
    1. Transferase
    2. Reductase
    3. Oxidoreductase
    4. Oxidase
  41. The rate limiting step in cholesterol biosynthesis is catalyzed by
    1. HMG-COA synthase
    2. HMG COA reductase
    3. 7-A hydroxylase
    4. mevalonate kinase
  42. Betaoxidation of odd carbon fatty acid chain produces
    1. Succinyl CoA
    2. Propionyl CoA
    3. Butary L CoA
    4. Malonyl CoA
  43. Aminoacid that can be protonated and deprotonated at neutral pH is
    1. Histidine
    2. Asparatic acid
    3. Glycine
    4. Leucine
  44. Bile salts are derived from
    1. Fatty acids
    2. Cholesterol
    3. Bilirubin
    4. Sulphuric acid
  45. Substance used during starvation is
    1. Glucose
    2. Ketone body
    3. Glycogen
    4. Fatty acid.
  46. Vitamin use for post translational modification of glutamic acid to gamma carboxy glutamate is
    1. A
    2. D
    3. E
    4. K
  47. The tissue with the highest total glycogen content is
    1. Liver
    2. Kidney
    3. Muscles
    4. Adrenals
  48. The normal pH of blood is
    1. 6.8
    2. 7.4
    3. 7.7
    4. 8.0
  49. Albinism an inborn error of metabolism is due to lack of
    1. Tyrosinase
    2. Homogenestic acid
    3. Hyaluronidase
    4. Phenyl alanine hydroxylase
    5. Tyrosine carboxylase
  50. Presence of bilirubin glucuronides in urine without urobilinogen suggests
    1. Obstructive jaundice
    2. Haemolytic jaundice
    3. Hepatocellular jaundice
    4. Cirrhosis of liver
  51. High blood cholesterol and diminished serum proteins are encountered in
    1. Atherosclerosis
    2. Hypothyroidism
    3. Obstructive jaundice
    4. Nephrotic syndrome
  52. GABA Gamma amino butyric acid) is
    1. Post synaptic excitatory transmitter
    2. Post synaptic inhibitory transmitter
    3. Activator of glia-cell function
    4. Inhibitor of glia cell function
  53. Which of the following vitamin is present in co-enzyme A
    1. Thiamine
    2. Pyridoxine
    3. Nicotinic acid
    4. Panothenic acid
  54. Benedict’s solution is not reduced by
    1. Sucrose
    2. Fructose
    3. Maltose
    4. Lactose
  55. Which of the following is surfactant in lung
    1. Palmitic acid
    2. Dipalmitoyl lecithin
    3. Phosphatidyl glycerol
    4. Linoleic acid
  56. In sickle cell anemia glutamine in beta chain is replaced by
    1. Arginine
    2. Alanine
    3. Valine
    4. Methionine
  57. Which of the following cytochromes is responsible for metabolism of drugs
    1. P-450
    2. C-3b
    3. C-3a
    4. C-2a
  58. Refsum’s disease is due to accumulation of
    1. Galactose
    2. Sorbitol
    3. Phytanic acid
    4. Sphingomyelinase
  59. In which of the following is malate shuttle seen
    1. HMP shunt
    2. Glycolysis
    3. Gluconegenesis
    4. Glycogenesis
  60. Squalene is an intermediate in the synthesis of
    1. Lecithin
    2. Cholesterol
    3. Fatty acids
    4. None of the above
  61. Deficiency of enzyme acid maltase produces
  1. Von gierke’s disease
  2. Pompe’s disease
  3. Amylopectinosis
  4. Limit dextrinosis

62. Cyanide acts by

  1. Forming a complex with hemoglobin
  2. Combining with erythrocyte membrane
  3. Inhibiting cytochrome oxidase
  4. Blocking O2 transport

63. Cholesterol is transported from liver mainly as

  1. LDL
  2. HDL
  3. VLDL
  4. Chylomicrons

64. Lipid synthesis is promoted by

  1. Cortisol
  2. Insulin
  3. Glucagons
  4. Catecholamines

65. Source of energy to heart predammantly

  1. Fatty acid
  2. Glucose
  3. Ketone bodies
  4. Glycogen

66.Dietary fibre is rich in

  1. Collagen
  2. Starch
  3. Pectin
  4. Proteoglycan

67.Biotin is necessary for

  1. Carboxylation
  2. Translation
  3. Transmination
  4. Hydroxylation

68.All of the following reactions take place inside mitochondria except

(a)    EMP pathway

(b)    Kreb cycle

(c)    Fatty acid oxidation

(d)    Oxidative phosphorylation

69.Von Gierke’s disease is due to deficiency of enzyme

(a)    Glucose-6-phosphatase

(b)    Glucose-1-phosphatase

(c)    Branching enzyme

(d)    Myophosphorylase

70.Which of the following is a non-reducing sugar

(a)    Maltose

(b)    Sucrose

(c)    Lactose

(d)    Glucose

Answer Key

  1. D
  2. C
  3. D
  4. D
  5. A
  6. C
  7. A
  8. A
  9. B
  10. C
  11. B
  12. B
  13. C
  14. A
  15. A
  16. C
  17. D
  18. B
  19. A
  20. A
  21. A
  22. D
  23. C
  24. A
  25. A
  26. D
  27. C
  28. D
  29. C
  30. A
  31. D
  32. D
  33. B
  34. D
  35. C
  36. B
  37. C
  38. B
  39. B
  40. A
  41. B
  42. B
  43. A
  44. B
  45. B
  46. D
  47. C
  48. B
  49. A
  50. A
  51. D
  52. B
  53. D
  54. A
  55. B
  56. C
  57. A
  58. B
  59. B
  60. B
  61. B
  62. C
  63. B
  64. B
  65. A
  66. C
  67. A
  68. A
  69. A
  70. B
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